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Symbol
Name
ID

Lrrc8a
leucine rich repeat containing 8A VRAC subunit A
MGI:2652847

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Agammaglobulinemia
Disease(s) Associated with LRRC8A	Agammaglobulinemia
agammaglobulinemia 5

Mouse Phenotypes

increased thymocyte apoptosis

abnormal thymus apoptosis

decreased T cell proliferation

abnormal thymus morphology

small thymus cortex

absent thymus corticomedullary boundary

abnormal thymus medulla morphology

small thymus

thymus hypoplasia

decreased thymocyte number

decreased DN2 thymocyte number

decreased DN3 thymocyte number

decreased DN4 thymocyte number

abnormal thymus physiology

abnormal B cell differentiation

decreased immature B cell number

decreased transitional stage B cell number

increased pro-B cell number

abnormal T cell differentiation

abnormal T cell selection

decreased double-negative T cell number

decreased double-positive T cell number

decreased marginal zone B cell number

decreased B cell number

decreased pre-B cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased regulatory T cell number

decreased T cell number

small spleen

increased IgG2a level

abnormal T cell physiology

Availability

Mouse Genotype

Lrrc8a^tm1.1Geha/Lrrc8a^tm1.1Geha

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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